Which class of medication can dangerously suppress the epinephrine response that normally signals impending low blood sugar?
Answer
Beta-blockers
A critical risk factor arises when diabetics who consume ackee (especially if possibly contaminated) are simultaneously taking beta-blockers. The body's normal physiological defense mechanism against impending hypoglycemia involves the release of the hormone epinephrine (adrenaline), which causes recognizable symptoms like tremors or rapid heart rate, signaling the need for glucose intake. Beta-blockers work by inhibiting this epinephrine response. Consequently, if a diabetic on beta-blockers ingests toxin-laced ackee and experiences a sudden drop in blood sugar, they will lack the crucial warning signs, making the resulting hypoglycemia much more severe and potentially fatal without immediate intervention.

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