What molecule, released upon TRPV1 activation, causes blood vessels to widen?

Answer

Nitric oxide

Nitric oxide is identified as the crucial signaling molecule in the cardiovascular system that is triggered for release following the activation of the TRPV1 receptor by capsaicin. Its primary function in this context is acting as a potent vasodilator. Vasodilation is the physiological process involving the relaxation and subsequent widening of the blood vessel walls. When blood vessels widen, the overall resistance encountered by the circulating blood decreases significantly. This reduction in resistance directly corresponds to a measurable decrease in blood pressure figures, suggesting that enhanced nitric oxide availability due to chili consumption could contribute to lowering both systolic and diastolic measurements.

What molecule, released upon TRPV1 activation, causes blood vessels to widen?
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