Which compounds in miracle fruit seeds reportedly reduced TC by 15% to 20% in hamsters?

Answer

Triterpenoids

The most direct preclinical evidence for cholesterol reduction comes from studies involving extracts derived specifically from the seeds of *Synsepalum dulcificum*. Researchers focused on chemical constituents known as triterpenoids, which are highly concentrated in this part of the plant structure. In animal models, specifically hamsters maintained on a high-cholesterol diet, the addition of these seed extracts resulted in a measurable and significant decrease in plasma Total Cholesterol (TC). The magnitude of this reduction was reported to be within the range of 15% to 20%. Further granularity in the research identified specific triterpenoids, namely *lupeol acetate* and *$eta$-amyrin acetate*, as the agents responsible for this systemic anti-hyperlipidemic activity observed in the test subjects.

Which compounds in miracle fruit seeds reportedly reduced TC by 15% to 20% in hamsters?

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