Which liver enzyme does pomelo consumption inhibit, leading to higher-than-intended drug levels in the bloodstream?
Answer
Cytochrome P450 3A4 (CYP3A4)
Pomelo, similar to grapefruit, contains compounds that are capable of blocking the function of the specific liver enzyme known as cytochrome P450 3A4 (CYP3A4). This enzyme is crucial because it is responsible for the metabolic breakdown of a significant percentage of prescription medications. When CYP3A4 is inhibited by the compounds in the fruit, the medication is metabolized much slower than expected. This results in the drug remaining in the bloodstream for prolonged periods, potentially elevating the concentration from a safe therapeutic dose to a toxic level, posing a significant safety risk to the patient.
Related Questions
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