What structural problem in diabetic kidney disease is addressed by reducing mesangial cell proliferation?
Answer
Reduced filtering capacity in glomeruli
A detailed finding regarding the mechanism of action involves the mesangial cells. These cells are crucial because they provide the necessary structural support within the glomeruli, which are the kidney's functional filtering units. A defining characteristic and a significant structural complication of diabetic nephropathy is the excessive proliferation—or uncontrolled growth—of these mesangial cells. When these cells multiply too much, they physically impede the normal function of the glomerulus, leading directly to a measurable reduction in the kidney's overall filtering capacity. Purple corn components appear to target this root structural cause by mitigating the proliferation.
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