What naturally occurring substance in kale affects the bioavailability of the calcium it supplies?
Oxalic acid
Although kale is recognized as a substantial plant source of calcium, an important consideration is how easily the body can utilize that mineral, known as bioavailability. This utilization is negatively impacted by the presence of oxalic acid within the leaf tissue. Oxalic acid has a strong chemical affinity for calcium, meaning it binds tightly to the calcium ions. This binding process significantly inhibits the body's ability to absorb the calcium into the system for use in bone building. The text contrasts kale with spinach, noting that while spinach contains more total calcium, its much higher concentration of oxalic acid makes kale’s calcium more readily available despite kale containing oxalates itself.

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Kale: Benefits of a superfood powerhouse - Mayo Clinic Health System