In *in vitro* digestion models, which extract showed greater inhibition of pancreatic lipase compared to seed extracts?

Extract made from the pulp and skin

When studying cholesterol management in the simulated environment of *in vitro* digestion, the activity of pancreatic lipase—the enzyme essential for breaking down dietary fats so they can be absorbed—is a critical target. Researchers compared the inhibitory effects of extracts derived from different parts of the fruit. Although the inhibition observed from the seed extracts was only described as moderate, the extract formulated from the pulp and skin components demonstrated a greater, albeit still moderate, inhibitory effect against the action of pancreatic lipase at the tested concentrations. This suggests that while seeds contain systemic agents, the pulp and skin possess compounds that interfere more directly with the enzyme responsible for initial fat breakdown during the digestive phase.