Which specific liver enzyme system is generally implicated when cautioning about potential drug interactions with citrus fruits?

Answer

Cytochrome P450 enzyme system

A general safety consideration for consuming high levels of citrus fruits involves potential interference with the body's drug metabolism processes, specifically through the cytochrome P450 enzyme system in the liver. While grapefruit is typically the primary citrus fruit cited for significant interactions here, the caution extends generally to limes due to their nature as citrus fruits containing bioactive compounds. This enzyme system is responsible for metabolizing, distributing, and excreting many prescription medications. If kaffir lime juice were consumed regularly or in medicinal quantities, the general citrus protocol suggests consulting a healthcare provider to ensure there is no unwanted interference with maintenance medications processed by this vital system.

Which specific liver enzyme system is generally implicated when cautioning about potential drug interactions with citrus fruits?

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