What toxic compound is present in Borage leaves and flowers used for tea infusions?

Answer

Pyrrolizidine alkaloids (PAs)

The primary safety concern associated with brewing tea from the aerial parts of the borage plant, specifically the leaves and flowers, is the presence of naturally occurring compounds known as pyrrolizidine alkaloids (PAs). Unlike borage seed oil, which is typically processed to remove these substances, the unprocessed herbs used for infusion retain them. These PAs are the source of serious toxicity risks, most notably hepatotoxicity, which means they can poison the liver, leading to severe conditions like veno-occlusive disease upon chronic exposure.

What toxic compound is present in Borage leaves and flowers used for tea infusions?
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