What serious condition results from the hepatotoxicity caused by chronic Borage PA consumption?
Answer
Veno-occlusive disease (VOD)
Veno-occlusive disease (VOD) represents the most severe potential outcome stemming from the liver damage caused by pyrrolizidine alkaloids (PAs) found in borage leaves and flowers. VOD specifically involves the blockage or damage to the blood vessels surrounding the liver. Chronic exposure to PAs, even at low levels over an extended period, increases the susceptibility to developing this condition. Indicators that suggest potential liver distress, which could be linked to VOD or general PA toxicity, include symptoms such as upper abdominal pain, vomiting, diarrhea, and hepatomegaly, which is an enlargement of the liver.
Related Questions
What toxic compound is present in Borage leaves and flowers used for tea infusions?What serious condition results from the hepatotoxicity caused by chronic Borage PA consumption?What component delivered by Borage seed oil poses a risk for prolonged bleeding time when consumed highly?Which collection of symptoms represents the mild, immediate gastrointestinal discomforts reported after Borage consumption?What specific danger related to PAs is a concern when borage is consumed by women who are breastfeeding?What physical feature covering the stems and leaves of Borage can cause minor skin irritation upon handling?If one is managing existing liver disease, what is the clear general consensus regarding the use of borage products?Which category of medication, when taken alongside Borage, might increase the toxic effects of PAs by affecting liver processing speed?What duration limit is suggested for the internal use of Borage leaves to mitigate the risk associated with PA exposure?What specific substance found in high amounts in borage purée has been linked to causing infant blood disorders?