Which cell populations are most critically impacted by the molecular havoc caused by Acute Radiation Syndrome (ARS)?
Answer
Those lining the gut or found in the bone marrow
The lethality associated with Acute Radiation Syndrome (ARS) is disproportionately linked to the damage inflicted upon tissues containing cells that divide rapidly. Among the body's systems, the cells lining the gastrointestinal tract (gut) and the hematopoietic stem cells residing in the bone marrow fit this description. Because these cells are constantly undergoing division and replacement, the instantaneous molecular damage caused by high-dose acute gamma exposure prevents necessary regeneration, leading directly to systemic failure, such as severe gastrointestinal distress and compromised immunity/blood production.
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