What mechanism does hot water immersion use to treat stingray venom?
Denaturing the protein-based venom
Stingray venom is fundamentally composed of proteins, and the most critical intervention for pain management involves applying intense heat. This heat acts as a denaturing agent, meaning it alters the molecular structure of these proteins, effectively rendering the venom inactive. When the protein structure is broken down, the venom can no longer exert its painful effects on the surrounding tissues. This process halts the venom's destructive action and is responsible for the dramatic reduction in agony experienced during the hot water soak. It is essential to maintain this high temperature because if the temperature drops or the duration is too short, some venom proteins may remain active, leading to recurring or persistent pain.

#Videos
Stingray fish injury - Everything You Need To Know - YouTube