What duration limit is suggested for the internal use of Borage leaves to mitigate the risk associated with PA exposure?
Answer
Four to six weeks
Because of the cumulative risk associated with chronic exposure to hepatotoxic pyrrolizidine alkaloids (PAs) present in the leaves and flowers, experts generally recommend strictly limiting the duration of internal consumption. The suggested safe window for consuming borage leaves is typically restricted to short periods, often cited as being between four to six weeks. This limitation is intended to minimize the time the liver is subjected to potential toxic insult from the PAs, reinforcing the need for caution even when consuming the fresh herb infusion.

Related Questions
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