In chronic metabolic acidosis, how does the body attempt to buffer circulating acid using skeletal reserves?
Answer
By releasing alkaline bone mineral for neutralization
When metabolic acidosis, particularly that resulting from chronic conditions like long-term kidney disease, persists, the body resorts to mobilizing internal buffers beyond the immediate chemical systems. One significant, albeit slow and damaging, source of buffering capacity is the skeleton. The bone mineral matrix contains alkaline substances that are slowly released into the bloodstream. This release acts to neutralize the excess circulating acid. However, the long-term consequence of repeatedly tapping into this reservoir is bone demineralization, highlighting the systemic risks associated with poorly managed chronic acidosis.
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