How does the lectin Tarin exert its noted antitumoral and antimetastatic activity in preclinical models?
Answer
By modulating the COX-2 enzyme pathway
Tarin, identified as a specific lectin present in taro, exhibits significant biological activity demonstrated in cell and animal models, showing both antitumoral and antimetastatic effects while remaining non-toxic to healthy cells at effective concentrations. A key mechanism identified for this activity involves the modulation of the COX-2 enzyme pathway. The COX-2 pathway is frequently observed to be overactive or upregulated in tumor environments. By modulating this pathway, Tarin effectively contributes to a reduction in pro-tumorigenic inflammatory mediators, thereby helping to suppress tumor progression and the spread of cancer cells.
Related Questions
What natural compounds in raw Taro root necessitate thorough cooking to prevent oral irritation?What role do the undigested carbohydrates, fiber and Resistant Starch (RS), play once they reach the colon?What percentage of the daily value for Manganese does a cooked cup of taro root typically provide?How does the lectin Tarin exert its noted antitumoral and antimetastatic activity in preclinical models?Which preparation methods are sometimes favored over boiling for retaining a higher percentage of water-soluble nutrients in taro?What beneficial substances are produced when gut microbes ferment the fiber and Resistant Starch (RS) found in taro?How does the Resistant Starch (RS) component in taro specifically contribute to better long-term blood sugar management?What specific indigenous name is used for Taro root (*Colocasia esculenta*) in Hawaiʻi?Which specific polyphenol is most frequently cited as the powerful antioxidant compound found within taro root?How does the substantial fiber content in taro assist individuals attempting weight management regarding food intake?Which essential mineral, abundant in taro, is crucial for cardiovascular support by counterbalancing excess sodium?