What are the primary receptor sites engaged by cannabis compounds in the body?

Answer

CB1 and CB2 receptors

The primary mechanism through which cannabis affects the body involves the endocannabinoid system (ECS), which is a natural network existing within the human body. Within this system are specialized receptor sites designed to interact with signaling molecules. The two most notable receptor types mentioned for cannabis interaction are CB1 and CB2. CB1 receptors are mainly located in the brain and central nervous system, mediating psychoactive effects. CB2 receptors are predominantly situated in peripheral tissues, often linking to immune system modulation. When cannabis compounds are introduced, they mimic the body's natural endocannabinoids by binding directly to these CB1 and CB2 receptor sites, thereby modifying the standard signaling processes occurring through the ECS.

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