Which enzyme system is potentially affected by citrus fruits like citron regarding drug metabolism?

Answer

Cytochrome P450

Citrus fruits, including but not limited to grapefruit, are recognized for their capability to interfere with how the human body processes many prescribed drugs. This metabolic interference primarily targets the liver enzymes known collectively as cytochrome P450. These enzymes are vital for the breakdown and elimination of numerous pharmaceuticals. If citron significantly impacts the function of these pathways, it can lead to an altered therapeutic effect of medications, potentially increasing their concentration to toxic levels or, conversely, reducing their effectiveness entirely. This metabolic caution is especially relevant for individuals taking long-term treatments for serious conditions such as heart disease or high cholesterol.

Which enzyme system is potentially affected by citrus fruits like citron regarding drug metabolism?

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