Which subjects demonstrated the preventative effect of Jerusalem artichoke fiber against metabolic syndrome markers?

Rats fed a high-fructose diet

The evidence establishing a link between Jerusalem artichoke fiber and metabolic protection stems directly from controlled preclinical research settings. Specifically, investigations focused on understanding how to counteract the deleterious effects of diets that mimic Western eating patterns, which often include high levels of refined sugars. In these experiments, rats were administered a high-fructose diet known to induce negative metabolic changes, including insulin resistance and fat deposition in the liver. The inclusion of soluble fiber derived from *Helianthus tuberosus* in the diet of these rats successfully mitigated the induction of both Type 2 diabetes and NAFLD, confirming the protective mechanism under high-stress dietary conditions.