SCFAs produced by gut fermentation exert systemic effects by influencing what processes?

Glucose metabolism and lipid regulation

The short-chain fatty acids (SCFAs) generated during the bacterial breakdown of inulin are crucial mediators of systemic health, extending their influence beyond the confines of the colon. Once these molecules enter the bloodstream, they interact with various tissues and signaling pathways throughout the body. The documented systemic effects include modulation of how the body manages blood sugar levels, specifically affecting glucose metabolism. Furthermore, SCFAs are deeply involved in regulating lipids—fats—in the body. By favorably influencing these two major metabolic areas, the fermentation products indirectly help prevent the characteristics of metabolic syndrome, such as ectopic fat storage in organs like the liver.