What limits the effectiveness of an Infectious Coryza vaccine regarding *A. paragallinarum* serogroups?

Answer

Poor or non-existent cross-protection between distinct serogroups.

A crucial aspect of managing Infectious Coryza via vaccination hinges on the immunological specificity related to the different bacterial serotypes of *A. paragallinarum*. The bacterium is categorized into distinct classifications, primarily serogroups 1, 2, and 3. Vaccines are manufactured to induce immunity against the specific serogroups they contain. However, a significant challenge arises because there is generally little to no cross-protection afforded between these different serogroups. If a vaccine protects only against serogroup 1 strains, and the outbreak is caused by a prevalent serogroup 2 strain circulating locally, the vaccination program will appear ineffective because the immune response is not tailored to neutralize the active circulating pathogen.

What limits the effectiveness of an Infectious Coryza vaccine regarding *A. paragallinarum* serogroups?

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