Why can herbicide formulations be significantly more toxic than their active ingredient?

Answer

Surfactants and adjuvants help chemicals penetrate plant tissue

Many commercial weed control products include additives such as surfactants and adjuvants that are designed to assist the chemical in penetrating plant tissues more effectively. When these additives are combined with the primary active chemical, the resulting formulation can exhibit toxicity levels far greater than the active ingredient alone. This mixture alters how the substance interacts with living organisms, potentially increasing the harm caused to humans or animals upon exposure compared to tests focused solely on the active compound.

Why can herbicide formulations be significantly more toxic than their active ingredient?
ToxicityhumanRiskherbicideexposure