Which excipient technique involves forming a cage-like structure to encapsulate the drug, rendering it more soluble?
Answer
Cyclodextrins
When physical state modification or co-solvent addition proves insufficient, complexation is employed as an advanced technique to enhance solubility. Cyclodextrins are specialized molecules used for this purpose because of their unique molecular architecture. They possess a hydrophilic exterior capable of interacting with water, surrounding an internal core that is often hydrophobic. The poorly soluble drug molecule can fit inside this cage-like structure. This encapsulation effectively shields the drug from the bulk solvent while presenting a more soluble complex to the aqueous environment, thereby increasing the overall dissolution capability.
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