What danger exists if a drug is not fully dissolved in an IV saline solution?

Answer

Precipitation within the vein causing blockages or embolisms

When administering medication directly into the venous system, such as via intravenous (IV) infusion, the requirement for complete dissolution is exceptionally immediate and critical. Unlike oral administration where dissolution occurs in the GI tract over time, IV delivery demands the drug be fully dispersed in the carrier fluid (saline solution) before entry. If solid particles remain suspended, they can aggregate and precipitate directly within the delicate vasculature of the veins. This physical blockage can lead to serious consequences, including thrombosis or the formation of embolisms, making high inherent water solubility a mandatory prerequisite for injectable formulations.

What danger exists if a drug is not fully dissolved in an IV saline solution?

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