Which specific compounds found in S. aizoon root extracts carry a strong warning for hepatotoxicity?
Answer
Pyrrolizidine alkaloids (PAs) such as senecionine
A critical safety concern associated with Sedum aizoon arises from its complex chemical makeup. While it offers significant cardiovascular and anti-fatigue benefits, its root extracts contain pyrrolizidine alkaloids (PAs), specifically exemplified by senecionine. PAs are a class of natural compounds notorious for their potential to cause severe liver damage. The presence of these hepatotoxic compounds underscores the necessity for precise identification and dosage control, as this toxicity contrasts sharply with the plant's recognized medicinal benefits.
Related Questions
What primary circulatory function earned Sedum aizoon the title "god medicine for hemostasis" in older classics?What topical issues were indigenous healers in the Mexican tradition reportedly treating with crushed leaf juice of Sedum dendroideum?What are the main active chemical groups identified as being rich in S. aizoon extracts?What chemical quality associated with tannins in S. dendroideum aids in its traditional topical wound repair?Which specific compounds found in S. aizoon root extracts carry a strong warning for hepatotoxicity?Excessive consumption of S. aizoon has been linked in older literature to which serious organ toxicity condition?What is the specific toxicity concern noted regarding large oral ingestion of Hylotelephium telephium (Orpine)?What beneficial results were demonstrated in human clinical trials using S. aizoon sap extracts on college students?Which Ming Dynasty text, detailing Traditional Chinese Medicine practices, explicitly recognizes Sedum aizoon as one of the 'Taibai seven medicine'?Why is respecting botanical specificity essential when cultivating Sedum for potential medicinal application?In preclinical models studying S. aizoon extracts, what specific improvements were noted regarding metabolic health?