What is the typical role of Proton Pump Inhibitors (PPIs) like omeprazole in GERD management?

Used for persistent or severe cases like esophagitis as strong acid blockers.

Proton Pump Inhibitors (PPIs), exemplified by drugs like omeprazole and lansoprazole, represent one of the strongest classes of medication used to manage gastroesophageal reflux disease by targeting acid production. Unlike antacids, which neutralize existing acid, or H2 blockers, which decrease acid output, PPIs work by irreversibly blocking the proton pumps in the stomach lining responsible for secreting acid. Because of their potent acid-suppressing capabilities, PPIs are generally reserved for managing more persistent or severe manifestations of GERD. This often includes conditions where significant esophageal irritation has occurred, such as esophagitis, where reducing the acid load significantly allows the damaged tissue time to heal.