Which molecular pathway related to inflammation is curcumin known to inhibit?
Answer
NF-κB pathway
The core mechanism by which curcumin exerts its anti-inflammatory effects involves interfering with key regulatory molecules in the inflammatory cascade. Specifically, curcumin has been shown to inhibit the NF-κB pathway. This pathway is crucial because it regulates the expression of numerous genes that drive the inflammatory response. By suppressing NF-κB activity, curcumin effectively dials down the genetic signals that promote chronic inflammation, which is implicated in many long-term illnesses.
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