How does Amlodipine affect the blood levels of Simvastatin?

Answer

Increase the blood levels of Simvastatin

Amlodipine can interact with certain cholesterol-lowering medications known as statins, specifically mentioning simvastatin and lovastatin within this group. The interaction mechanism results in amlodipine causing an elevation in the circulating blood levels of these statins. This elevated concentration of the statin drug is clinically significant because it increases the probability and severity of adverse effects commonly associated with those cholesterol treatments. Muscle pain (myalgia) is one of the recognized adverse effects that becomes more likely when statin levels rise above their target range. Therefore, when a patient is prescribed both amlodipine and a statin like simvastatin, careful monitoring is necessary to mitigate the risk of these heightened side effects resulting from the pharmacokinetic interaction facilitated by the liver metabolism pathways common to both drugs.

How does Amlodipine affect the blood levels of Simvastatin?

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