Which specific substance is frequently cited as the single most common *allergen* for ACD?
Answer
Nickel
When specifically considering chemical substances that trigger Allergic Contact Dermatitis (ACD) through immune sensitization, nickel consistently emerges as the most frequently reported single allergen across various patient populations and studies. Its ubiquity in modern materials—including costume jewelry, belt buckles, cell phone casings, and even trace amounts in gold alloys—leads to widespread exposure. This high degree of contact, combined with its capacity to elicit a strong T-cell response in sensitized individuals, solidifies its position as the top allergen, even though categories like fragrances and preservatives are also highly common sensitizers overall.
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