Which condition is a key risk factor for severe, disseminated E. tarda infection involving mortality?
Answer
Hepatobiliary Disease/Cirrhosis
While multiple conditions increase susceptibility, Hepatobiliary Disease or Cirrhosis stands out as a primary risk factor specifically associated with the highest danger, namely mortality from E. tarda bacteremia. Liver dysfunction, including cirrhosis arising from conditions like Hepatitis C or NASH, creates a synergy where impaired immune function combines with potential iron dysregulation, making the infection exceptionally dangerous. This factor is repeatedly identified as an independent predictor for fatal outcomes in patients experiencing systemic E. tarda infection.
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