What factor limits confirmation of Cordyceps blood sugar regulation in humans?

There is a lack of significant clinical trials in humans to confirm promising antihyperglycemic lab results.

While Cordyceps extracts show promising antihyperglycemic effects in animal models, specifically improving fasting blood glucose levels and glucose tolerance in diabetic rats, this benefit has not been definitively translated to the human population. The primary limitation is the scarcity of rigorous, significant clinical trials conducted specifically on humans to confirm this blood sugar-lowering potential. Therefore, while cordycepin and certain Free Fatty Acids present in the fungus suggest mechanisms for triggering insulin release, individuals managing diabetes must exercise extreme caution, as combining the supplement with existing medication could theoretically cause blood sugar to drop dangerously low (hypoglycemia) without robust human data to establish safe dosing.