What specific compounds found in soursop leaves warrant caution regarding excessive, long-term use?
Answer
Annonaceous acetogenins
A crucial safety consideration when consuming soursop leaf preparations, especially over long periods or in large quantities, involves the presence of annonaceous acetogenins. These naturally occurring compounds within the leaves have been studied for their significant biological activity. Concerns arise because extremely high doses, sometimes found in specific extracts, have been associated with potential neurotoxic effects, necessitating a cautious approach to regular, heavy intake. This fact underscores the general advice to practice moderation with potent herbal remedies.
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