What is the chemical goal of immersing the affected limb in hot water for Man o' War pain management?
Answer
Thermal denaturation of the venom proteins
The most consistent and highly recommended treatment for the intense pain following Man o' War stings is prolonged immersion in hot water. The underlying principle behind this treatment is the heat's ability to cause thermal denaturation of the venom proteins. Heat disrupts the complex structure of these proteins, rendering the venom biologically inactive and significantly reducing the pain signal transmission, thus forming the cornerstone of post-tentacle acute pain management.
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