How does poor ventilation increase the severity of *A. paragallinarum* infection?
Answer
Rising ammonia levels irritate and damage respiratory lining.
Poor ventilation traps airborne irritants generated from accumulated droppings and litter, primarily resulting in high concentrations of ammonia gas. This buildup acts as a significant stressor on the birds' respiratory system. The elevated ammonia levels irritate and cause physical damage to the delicate mucous lining of the respiratory tract. This physical disruption compromises the bird's natural defenses, creating an advantageous entry point and environment for *Avibacterium paragallinarum* to successfully colonize the host tissues, even when the initial exposure dose might have been low.
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