What hallmark sign characterizes liver involvement during the severe phase of leptospirosis?
Answer
Jaundice, the yellowing of the skin and the whites of the eyes
When the infection severely impacts the liver, a classic and highly indicative symptom that develops is jaundice. Jaundice manifests visibly as the yellowing discoloration of the skin and the sclera (the whites of the eyes). This occurs because the impaired liver function leads to a buildup of bilirubin in the body, which is then deposited in these tissues. The appearance of jaundice signifies that the disease has entered a critical stage, often categorized under the historical term Weil's disease, requiring intensive supportive care alongside primary antibiotic therapy.
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