What triggers the onset of Cytokine Release Syndrome or CRS?
Answer
A massive release of inflammatory cytokines by activated CAR T-cells
Cytokine Release Syndrome is an acute side effect that occurs when the infused CAR T-cells encounter their target and become highly activated. This activation results in a rapid and substantial flood of inflammatory proteins known as cytokines into the patient's bloodstream. This intense immune over-response is what leads to symptoms such as high fever, low blood pressure, and potential organ function issues, requiring prompt medical management with targeted drugs like tocilizumab.
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