What is the purpose of bridging chemotherapy during the waiting period?
Answer
To manage tumor progression until the cells are ready
The manufacturing of personalized CAR T-cell products takes several weeks, during which the cells are engineered and multiplied. For patients with aggressive malignancies, this wait time can be risky because the cancer may continue to grow. Bridging chemotherapy is used during this interval as a temporary treatment to keep the tumor burden under control and prevent disease progression while the custom-made CAR T-cell therapeutic dose is being prepared, validated, and shipped for infusion.
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