What defines the expansion phase in the CAR T-cell manufacturing protocol?
Answer
The multiplication of modified cells into a therapeutic dose
The expansion phase is a crucial manufacturing step where the successfully engineered T-cells are grown in a laboratory environment to increase their numbers. The goal is to reach a therapeutic dose, which often requires billions of cells. This expansion allows the initial small sample to grow significantly, ensuring that when the final product is infused, there are enough active cells present to overwhelm the cancer burden in the patient's body.
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