Which specific components, alongside KGM and MOFs, were loaded into engineered hydrogels to demonstrate enhanced localized anti-inflammatory activity?

Answer

Pterostilbene

The application of KGM extends into advanced material science where it forms the matrix for therapeutic scaffolds designed to manage localized inflammation at a repair site. Researchers engineered composite hydrogels that utilize KGM for structure and biocompatibility, combined with metal-organic frameworks (MOFs) to act as carriers. Crucially, these scaffolds were specifically loaded with the bioactive compound pterostilbene, known for its inherent anti-inflammatory qualities. When these KGM-MOF-pterostilbene constructs were tested on LPS-stimulated RAW264.7 cells, they successfully downregulated factors like TNF-$\\alpha$, IL-6, and IL-1$\\beta$. This shows that the KGM matrix successfully integrates and supports the therapeutic function of the co-delivered bioactive agent against inflammation-induced cellular damage.

Which specific components, alongside KGM and MOFs, were loaded into engineered hydrogels to demonstrate enhanced localized anti-inflammatory activity?

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