In models of oxazolone-induced colitis (OXA) in mice, which two specific interleukins were markedly reduced by KGM administration?

Answer

Interleukin-4 (IL-4) and Interleukin-13 (IL-13)

Evidence supporting KGM's effectiveness against intestinal inflammation comes clearly from studies using animal models designed to mimic conditions like colitis. Specifically, in research involving oxazolone-induced colitis (OXA) in mice, the administration of KGM demonstrated a significant clinical benefit by lessening the severity of the inflammatory symptoms. This observed therapeutic effect was directly correlated with molecular changes, namely a significant downregulation in the levels of specific pro-inflammatory mediators. The text points out that the reduction of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) was a key finding associated with KGM intervention in these gut inflammation models, illustrating its ability to suppress key inflammatory signaling molecules present during active colitis.

In models of oxazolone-induced colitis (OXA) in mice, which two specific interleukins were markedly reduced by KGM administration?

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