What specific immunological marker associated with allergic responses does Pulverized Konjac Glucomannan (PKGM) help suppress in models of skin inflammation?

Answer

Hyper-IgE

The scope of KGM's anti-inflammatory benefits reaches beyond the gut and into systemic allergic and skin manifestations, such as atopic dermatitis observed in mouse models. When Pulverized Konjac Glucomannan (PKGM) was tested in these experimental settings, it demonstrated a clear capacity to calm the hyperactive immune response characteristic of allergic conditions. Specifically, PKGM activity was shown to actively suppress the production of hyper-IgE (Immunoglobulin E). High levels of IgE are the definitive hallmark of allergic reactions, signaling mast cell degranulation and the resulting inflammation. Therefore, the suppression of this specific antibody marker strongly indicates KGM's role in dampening the underlying immunological drivers behind allergic and inflammatory skin issues.

What specific immunological marker associated with allergic responses does Pulverized Konjac Glucomannan (PKGM) help suppress in models of skin inflammation?

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