Which central pathway involved in initiating inflammatory responses is modulated by Konjac Glucomannan (KGM)?

Answer

The nuclear factor kappa B (NF-$\\kappa$B) pathway

The complex anti-inflammatory mechanism attributed to Konjac Glucomannan extends beyond simple cytokine suppression; it involves modulating core regulatory systems within the cell. A crucial finding highlights that KGM influences the nuclear factor kappa B (NF-$\\kappa$B) pathway. The NF-$\\kappa$B pathway is globally recognized as a master regulator, playing a central and pivotal role in the initiation and transcription of numerous genes that drive inflammatory processes throughout the body. By modulating or suppressing the activation of NF-$\\kappa$B, KGM effectively targets inflammation at a transcriptional level, offering a deep mechanism of action that complements the direct reduction of downstream effectors like TNF-$\\alpha$ and IL-1$\\beta$.

Which central pathway involved in initiating inflammatory responses is modulated by Konjac Glucomannan (KGM)?

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