How does the intrathecal delivery route compare to IV infusion regarding procedural impact?
Answer
It bypasses lung and liver filtration, ensuring more cells reach the CNS.
The method by which stem cells are delivered significantly impacts procedural complexity and final cost. Intravenous (IV) infusion subjects the cells to filtration by the lungs and liver as they circulate systemically. In contrast, the intrathecal route involves a more invasive procedure where cells are delivered directly into the spinal fluid. This direct injection into the central nervous system environment is advantageous because it bypasses the systemic filtration processes, ensuring a higher concentration of viable cells potentially reaches the target area immediately.
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