Which specific complication of brucellosis demands the most aggressive management approach, frequently requiring surgical intervention?
Answer
Endocarditis (infection of the heart valves)
Infection of the heart valves, medically termed endocarditis, represents the most life-threatening complication arising from systemic *Brucella* infection. This condition necessitates the most intense level of medical intervention available due to the critical role of the heart valves in cardiovascular function and the high risk of catastrophic failure. Treatment protocols mandate prolonged, aggressive antibiotic therapy delivered intravenously (IV) to maintain high systemic concentrations. Crucially, the likelihood of permanent cure is often tied to surgical intervention, frequently requiring the removal or replacement of the infected valve itself.
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