In uncomplicated brucellosis treatment, what is the main disadvantage of the Doxycycline plus Aminoglycoside combination compared to the oral regimen?

It requires parenteral (injectable) administration, often necessitating initial hospitalization or frequent clinic visits.

The pairing of Doxycycline with an aminoglycoside like gentamicin or streptomycin achieves a shorter total treatment duration, often around three weeks, which can be appealing. However, this benefit is offset by the delivery method required for the aminoglycoside component. Since aminoglycosides must be administered parenterally (via injection), this regimen imposes a significant logistical burden on the patient, requiring either mandatory initial hospitalization or frequent, scheduled visits to a clinic for injections. This dependency on professional administration can create substantial barriers to patient adherence compared to the entirely oral, six-week Doxycycline plus Rifampin regimen.