How do pesticides classified as Endocrine-Disrupting Chemicals (EDCs) affect hormone function?
They can mimic natural hormones or block hormone receptors.
Endocrine-Disrupting Chemicals (EDCs) pose a significant chronic health risk because they specifically target the body’s endocrine system, which relies on precise hormonal regulation. These chemicals interfere with this system through several modes of action. A primary mechanism involves molecular mimicry, where the EDC structure is similar enough to a natural hormone (like estrogen or testosterone) that it can bind to and activate the hormone's receptor site, initiating a response where none should occur. Conversely, EDCs can also act as antagonists, binding to the receptor site without activating it, thereby physically blocking the natural hormone from binding and exerting its intended effect. Since hormones govern fundamental processes like growth, metabolism, and reproduction, subtle interference through these mimicking or blocking actions can lead to widespread physiological consequences.
