Exposure to aristolochic acid is linked to what specific inflammatory kidney condition?

Answer

Rapidly progressive interstitial nephritis.

The primary chemical hazard associated with the *Aristolochia* species is the presence of aristolochic acids, which are potent nephrotoxins. The ingestion of these compounds is directly implicated in causing a severe form of kidney injury known as rapidly progressive interstitial nephritis. This condition is characterized by acute inflammation that specifically targets the interstitial tissue—the area surrounding the renal tubules within the kidney structure. This inflammatory response causes swift damage and scarring to this critical supportive tissue, leading rapidly to a major reduction in overall kidney function and often progressing quickly toward end-stage renal disease requiring life-sustaining treatments like dialysis.

Exposure to aristolochic acid is linked to what specific inflammatory kidney condition?

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