What defines Uhthoff's phenomenon in individuals with Multiple Sclerosis?
Answer
Symptoms worsen when the core body temperature rises
In individuals diagnosed with Multiple Sclerosis, the protective covering of the nerves, known as myelin, is damaged. This damage impairs the nerves' ability to conduct electrical signals efficiently. When the core body temperature rises, even slightly, this heat interferes further with nerve conduction in these already demyelinated nerves. This phenomenon, known as Uhthoff's phenomenon, leads to a temporary or sometimes sustained worsening of neurological symptoms. As the body struggles to cool down, the increased temperature exacerbates the underlying neurological impairment.
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