What chemical does capsaicin deplete with repeated topical application?
Answer
Substance P
Capsaicin, derived from chili peppers and applied externally, utilizes a specific mechanism to reduce pain signaling over time. While it initially generates a warming sensation, its sustained therapeutic effect comes from its ability to deplete Substance P. Substance P is a crucial chemical neurotransmitter responsible for transmitting pain messages from the site of injury or irritation up to the brain. By depleting this substance locally, capsaicin effectively reduces the efficacy of the body’s system for sending continuous pain signals.
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