What is the reported short-term safety profile for administering autologous or allogeneic MSCs?

Answer

Appears relatively safe with generally mild and transient adverse events

Current clinical research investigating the administration of Mesenchymal Stem Cells (MSCs), whether they are derived from the patient (autologous) or a donor (allogeneic), indicates a relatively favorable short-term safety profile across various trials. Adverse events that have been documented are usually characterized as being mild and transient in nature. These minor reactions are often related directly to the physical process of the injection or infusion itself, such as temporary localized discomfort or a slight fever. Despite this short-term appearance of safety, the lack of extensive, large-scale, long-term safety data is a major factor causing regulatory caution regarding widespread approval.

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