What chronic pulmonary condition frequently follows acute paraquat poisoning?
Answer
Pulmonary fibrosis
The lungs are a primary target organ for paraquat, and the resulting damage often leads to severe, life-threatening complications. The redox cycling caused by the toxin results in extensive inflammation and oxidative stress within the lung tissue. This damage typically progresses to pulmonary fibrosis, where the lung tissue becomes scarred and stiff. This scarring prevents proper gas exchange, leading to severe respiratory failure. This fibrotic phase is often the terminal event in paraquat poisoning, and because the structural damage to the lung tissue is so profound and irreversible, mechanical ventilation is often futile in the later stages.
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